Prevalence of TECTA and GJB2 mutations in Asian children with nonsyndromic hearing loss: A meta-analysis

Introduction: The most common sensory disorder, hearing loss, may result from genetic causes. Various inheritance patterns exist, such as X-linked, autosomal dominant, recessive, and mitochondrial. However, the underpinnings of racial distinctiveness regional variation were incompletely understood. To fully evaluate ethnic specificity gap junction protein beta 2 (GJB2) tectorin alpha (TECTA) mutations in this region, data all GJB2 TECTA gene studies on Asian children with impairment pooled used research. Methods: All nonsyndromic loss prevalence or published between 1990 2022 retrieved PubMed database, evaluated for risk bias, meta-analyzed. Results: Twelve chosen, representing twelve estimates. patients was 13.36% (95% confidence interval [CI]: 7.74%–20.14%), varying significantly among trials (I2 = 96.74%; P < 0.001). 3.6% CI: 1.9%– 5.7%) 24.06% 11.43%–31.35%), respectively. Conclusions: There an association TECTA/GJB2 impairment, but there also differences mutation prevalence. Studies larger sample sizes analyses based long-read sequencing are needed to understand resulting loss.